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Author Topic:   Who can tell me about synthing Ephedrine?
Xanion
Member
posted 12-19-1999 01:09 AM     Click Here to See the Profile for Xanion     
It is time to start talking about our main percursor Ephedrine and how to secure our future. Am i going Hydroponic for Y2K? Id rather twist a phenylsomethingamine over slow enough to attract an alcohal then trying to stain my thumb green.


X

Stonium
Member
posted 12-19-1999 01:25 AM     Click Here to See the Profile for Stonium     
Check on Rhodium's page, think there's a synth there.

Stonium

111/tri/cl/eth/ane
Member
posted 12-19-1999 01:41 AM     Click Here to See the Profile for 111/tri/cl/eth/ane     
green thumb is a great idea but who grows there own tobaco???? Dry distilation w/ steeam?????? use lye and salt the shit first/ the stuff should float on the lye watr layer or at least go into solvent, but at low concentrations proally forms an azetroph the good shit dont spontaniously XTYL out of solutions like ethanal, they need be slow leuted this love alch and must be brouht out very carefully they will try to escape saslting up

Xanion
Member
posted 12-19-1999 02:11 AM     Click Here to See the Profile for Xanion     
So we salt the bastards by nukin em ...in the microwave...? or UV...?


X

Xanion
Member
posted 12-19-1999 09:04 AM     Click Here to See the Profile for Xanion     
This looks like my best shot if I had no thumbs:

Author: Grue-Sorensen, Gunnar; Spenser, Ian D. Reference: Journal,

CJCHAG, Can.J.Chem., EN, 67, 1989, 998-1009 Title: The biosynthesis of

ephedrine Abstract: It is shown by 13C nuclear magnetic resonance

spectroscopy that the labelled C2 fragment of <2,3-13C2>pyruvic acid is

transferred intact into the C-methyl group and the adjacent carbon atom

of the Ephedra alkaloids, norephedrine, ephedrine, norpseudoephedrine,

and pseudoephedrine, in growing plants of Ephedra gerardiana.This

finding serves to identify pyruvate as the elusive precursor of the

aliphatic C2 terminus of the skeleton of the alkaloids.In earlier

experiments with 14C-labelled substrates, label from <3-14C>pyruvic acid

was incorporated mainly, but not exclusively, into the C-methyl group of

ephedrine, and label from <2-14C>pyruvate was incorporated similarly

into the carbon atom adjacent to the C-methyl group.A C6-C1 unit related

to benzaldehyde or benzoic acid has long been known to generate the

benzylic fragment of the carbon skeleton of the Ephedra alkaloids.It is

likely that the carbon skeleton of ephedrine is generated from pyruvate

and either benzaldehyde or benzoic acid, by a reaction analogous to the

formation of acetoin or diacetyl from pyruvate and acetaldehyde or

acetic acid, respectively.Key words: biosynthesis of ephedrine, Ephedra

alkaloids, 13C NMR spectra, ephedrine, biosynthesis of pyruvic acid,

incorporation into ephedrine 13C NMR spectra. CNR: 5725553


X

Xanion
Member
posted 12-19-1999 09:14 AM     Click Here to See the Profile for Xanion     
And FwhoopswageredclausHyooPhucKing111ironman how did you know I smoked? Our only real challeng will be to continue to foster youre outwardly sociall devopment of youre many differant personalities, by encouraging frequent discourse between them, whilst protecting youre inner wellness...!!!!


X


ps one of youre personalaitys was a hacker in a previous life or you are an ex adminsterator that they cant get rid of.aarrgggg!!!!!!

Uncle Fester
Member
posted 12-19-1999 02:50 PM     Click Here to See the Profile for Uncle Fester     
If I was doing this, I'd prefer to use the yeast fermentation of benzaldehyde, or the reaction between benzaldehyde and alanine. I know benzaldehyde is a list one chemical, but for small amounts there is oil of bitter almonds. For larger amounts there is that really good old industrial process using electrically generated Mn+3 to oxidize toluene to benaldehyde. My real preference would be to start with ethyl phenylacetate and hydrolyse to phenylacetic acid. Once I have that stuff, making lots of high quality meth is a cakewalk.

111/tri/cl/eth/ane
Member
posted 12-19-1999 03:58 PM     Click Here to See the Profile for 111/tri/cl/eth/ane     
I wouldent shit ya about this .....Ya got to salt up the water stuff with the crystal....them pills might even big big for a reason of course if ya didnt want to crystalize the stuff there would be simpler solutions like ussing a sponge or mixxing the stuff with oil,,, This is essentially why I am pushing the alum salt idea but ya could possibly use some supper dry salt maybe ya could mixit with some dry epsom and mix this with a little regular salt stuff and adjust to netral pH and umm salt it up like that personally I think ya should choose dimandofication

Dont trust them pill supporters anytime never they are there to dissuade you from a true and sucessfull outcome use natural or skip pills altogeterh, unless ya know of the umm yes complications involved you dont have a changch theey are many and varied>>>...

I dont belive in Santa ZClause neither so why sould I belive inn you???

111/tri/cl/eth/ane
Member
posted 12-19-1999 04:10 PM     Click Here to See the Profile for 111/tri/cl/eth/ane     
Sory about that catalys prblem it was accetycysteene so sorry there chap I was confused I cant smell the accetycysteene but I shure as hell can smell almonds smell like Cynide also??? what about h2s and where is your soap I think you plan to employ the acedic acid as the soap correct me if I am right/wrong???? Anyways accetylecysteene is available it is in booze at certain proofs and even used as a flavor in some lower prooff beverages as well it can be synthesized but like I said I can not smell it ,, umm suppossably makes ya puke umm it is available redially available did you use tooth paste to keep the paste wet and what about that soap and a little dirt to bust um the emmulsion when trying to extaract????
Carbon must of course be used unless ya plan to carbonate your umm stuff this black stuff flakes out if ya dont use carbon essentially wasting meterial burning it up and sendingthe unbernt stuff into the solution of which the ammonia stuff the nitro is obviosly burned up last I aint positive but the CN can proally be tested for simply enough in such cases otherwise the addation product produced if not carefully controled will produce carcongenis addations to the ammine first of was that to be incorporated into the acedic acid somehow, I am not in agreement over the ester idea excccept i am interested in the umm yes the estrification of stuff and reforations if to what end does this serve I aint shure most notably ya can proally rezip the stuff but this does not seem entirely good, so without soap formming this can in fact this is replaced by a stirring and cyclonization??? Humm maybe that ester is alot coolorer on the idease to employ it this seems like a nobel idea too bad I am not thinking critically on the application of it in this contolable reaction resulting from it deployment what might be interesting is turning the ester back into ammine this can be done can you explain so that it can be umm preformed I think this ould be well to provide for the deestrification because ya just seemingly made pseudo ephedrine out of plain ephedrine as far as I can tell for the information I use to serve my purposes????

Lost in Bermuda Triangle???

111/tri/cl/eth/ane
Member
posted 12-19-1999 04:56 PM     Click Here to See the Profile for 111/tri/cl/eth/ane     
acetaldehyde and benzaldehyde are
added to a carbohydrate solution actively fermenting by yeast, levorotatory
1-phenyl-2-ketopropan-1-ol, is formed. This compound on reaction with
methylamine and catalytic reduction yields l-ephedrine directly.
GUEESE NOT YOU HAVE BEEN BUZZY LATELY THANKYOU FOR THAT REF THERE PAL

How about accetylcystiene what ya gona find there???

111/tri/cl/eth/ane
Member
posted 12-19-1999 05:16 PM     Click Here to See the Profile for 111/tri/cl/eth/ane     
Take it back to the inteligence of a yest or a bug or a plant pathway and all of a suddent that seemingly immposible tower does in sact seem pretty not so impressive

Um there of course are different idease to different methods never deny that anture should be cited and also used to suppoort your synthetic design methodology good day then

All times are CT (US)

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